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Screening with cervical cytology and hrHPV testing can lead to harms, including more frequent follow-up testing and invasive diagnostic procedures eg, colposcopy and cervical biopsy , as well as unnecessary treatment in women with false-positive results. The USPSTF concludes with moderate to high certainty that screening women older than 65 years who have had adequate prior screening and are not otherwise at high risk for cervical cancer, screening women younger than 21 years, and screening women who have had a hysterectomy with removal of the cervix for indications other than a high-grade precancerous lesion or cervical cancer does not result in a positive net benefit. Sign in to access your subscriptions Sign in to your personal account. Loss to follow-up and disparities in treatment are also contributing factors. Regular screening for prevention of cervical cancer is highly effective, whether it is with cervical cytology alone, hrHPV testing alone, or both in combination. Implementation should therefore focus on ensuring that women receive adequate screening, regardless of which strategy is used.

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Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer:

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Screening for Cervical Cancer. Although screening with hrHPV testing alone or in combination with cytology detects more cases of CIN 2 and CIN 3, this method results in more diagnostic colposcopies for each case detected. Age-stratified 5-year risks of cervical precancer among women with enrollment and newly detected HPV infection. Protecting the underscreened women in developed countries: These recommendations also do not apply to individuals with in utero exposure to diethylstilbestrol or those who have a compromised immune system eg, women living with HIV.

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